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For other genes, either no hits or multiple sequences that have high similarity to the Arabidopsis gene but differ significantly one from another were found.
The generality of a YXXE motif, whether this motif is an obligated component in dityrosine bond formation, or whether there are multiple sequences that could mediate dityrosine bond formation requires further testing in other membrane proteins.
Directed evolution studies also suggest that epistatic paths can be bypassed (and they certainly are in laboratory evolution), because there are multiple sequences that satisfy a given fitness goal, and there are many different paths to these sequences [34], [71], [72].
Each CRM1 cargo contains multiple sequences that match NES consensus patterns but most of these sequences are not functional export signals.
Although the mib2 enhancer contains multiple sequences that can bind both Slou and other HD TFs, it – like the lbl enhancer – possesses one evolutionarily conserved Slou-preferred binding site (Fig. 4A,B; supplementary material Fig. S3B).
There are multiple sequences that express solute carrier Na+/Ca2+- and Na+/K+/Ca2+-exchange families of transport proteins that with expression of the coral Ca2+/H+-antiporter may regulate cellular pH and Ca2+ homeostasis.
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In the proposed system, each moving human can potentially be observed from multiple cameras, generating multiple observation sequences that can be used for activity recognition (see Figure 4).
The prediction of tertiary interaction motifs is difficult without multiple, related sequences that are usually not available.
Multiple protein sequences that are exactly the same can be eliminated by SQL with a simple automated function to yield a distinct protein list of all implicated proteins that differ by at least 1 amino in the protein sequence.
These results demonstrate that flow cytometric selection of RNAi knockdown cells combined with deep sequence analysis can be used to identify multiple shRNA sequences that reduce target gene expression to predetermined levels.
Therefore, we identified GO classes that were overrepresented within our dataset compared to the Gene Ontologies for the D. melanogaster proteome using Fisher's exact test, and counted multiple assembled sequences that matched to unique Drosophila proteins (Additional file 1).
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