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The multiple sequence and antigenic variability of HIV-1 has led to unprecedented difficulties in the development of effective vaccines.
The web application allows for a wide variety of searches and data analysis including protein motifs with chemical fragments association, protein sites characterisation, correlating properties, hits multiple sequence and 3D alignments.
To identify the specific functional residues on the CID, a multiple sequence and structure alignment of this domain was constructed.
Re-formatting is a time consuming element of multiple sequence and phylogenetic analysis and for that reason PATRISTICv1.0 creates no new intermediate formats.
Protein similarities and identities were determined by multiple sequence and pairwise alignments of full-length proteins, omitting the SP if present [ 58, 59].
The kinase domain sequences of all the CpPKs and the following structures (PDB: 2WEI, 2QG5, 3HKO, 2QKR, 3EB0, and 3OZ6) were submitted for multiple sequence alignment to the PROMALS3D multiple sequence and structure alignment server http://prodata.swmed.edu/promals3d/promals3d.php[ 66].edu/promals3d/promals3d.php[
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(3) Combined information from both multiple sequences and multiple structures.
Móricz [7] continued with the study of multiple sequences and gave some remarks on the notion of regular convergence of multiple series.
Agnew [6] studied the summability theory of multiple sequences and obtained certain theorems which have already been proved for double sequences by the author himself.
Phred [39]was used to assess sequence data quality and ClustalW [40] was used to align multiple sequences and identify polymorphisms.
We tested multiple sequences and chose GGATCCTCTGGCAGATGT, identified and designated shRNA H760.
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