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It has been pointed out that the polyspecificity/broad substrate specificity of ABC transporters due to multiple separate binding sites or "binding zones," binding sites accommodating more than one ligand and high protein flexibility determine a complex phenomenon which can only be partially addressed by current methods in the computational drug design field [ 23, 24].
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If make_withdraw is called again, then it will create a separate frame with a separate binding for balance.
The first mission launches multiple separate deorbit kits.
Beside leading to more accurate models due to inclusion of multiple (separate) parts of conformational space of the ligand-protein complex [18, 20], this scheme made LIE models independent from the a priori selection of ligand-binding poses, laying the basis for fully unsupervised LIE free energy predictions.
The NADP+ and ferredoxin have separate binding sites in FNR.
The less dense network can be explained by the presence of multiple patches and clusters of spatially separated binding and active sites.
Finally, detailed analysis of CTCF footprints suggests multiple modes of binding and a novel DNA binding motif upstream of the primary binding site.
Wu, H. et al. Unusual processing generates SPA lncRNAs that sequester multiple RNA binding proteins.
We show that naturally occurring binding sites for the Ubx-encoded protein contain clusters of multiple individual binding site sequences.
It is noteworthy that genes activated by SCL usually harbour multiple SCL binding sites, whilst repressed genes show much fewer binding events.
Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites.
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