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4 Recent studies showed that most treatments cause multiple secondary effects like exacerbation of autoimmune response, generation of new autoimmune disorders, and others.
At the same time, our results illustrate the complexity of the stress response that is characteristic of cross-talk pathways [ 8- 14] and multiple secondary effects from prolonged treatments.
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These observations demonstrate the complexity of the RpoE2 regulatory circuit and suggest that rpoE2 overexpression may result in multiple, secondary regulatory effects.
Depletion (loss of mtDNA) and multiple deletions are typically secondary effects of faulty mtDNA maintenance, from mutation of nDNA-encoded mitochondrial proteins.
Examination of effect sizes and confidence intervals showed notable effects for multiple secondary NSSI characteristics: number of lifetime incidents, number of NSSI forms and functions and perceived dependence on NSSI.
Finally, microRNAs might silence gene expression by a common and unique mechanism; and the multiple modes of action represent secondary effects of this primary event [ 1- 3].
While a subset of pervasive transcription products themselves may be noise, multiple mechanisms must exist to keep secondary effects of their production in check.
There may be an underlying genetic basis for the co-location of QTL observed in this study, reflecting pleiotropic effects of single loci influencing multiple secondary metabolite compounds.
All eight patients, representing 13 ulcers, tolerated multiple treatments with fetal biological bandages showing no negative secondary effects and repair processes similar to that seen in 3rd degree burns.
The present study was designed to compare the diagnostic sensitivity of these criteria at initial presentation, the time to fulfilling them, and secondary effects of ethnicity in pediatric-onset multiple sclerosis.
Anabolic steroids act on multiple organs and metabolic pathways either through primary interaction or secondary effects.
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