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The S1P field has surpassed the LPA field in therapeutic exploration because the S1P receptor agonist FTY720 is now near completion of phase III clinical trials for the treatment of multiple sclerosis, whereas no LPA-based therapeutic has advanced this far.
Probably the most important feature of the model is that, in the clinical and pathological presentation, EAE in marmosets more closely resembles multiple sclerosis, whereas the corresponding models in rhesus monkeys rather resemble acute neuroinflammatory diseases, such as acute disseminated encephalomyelitis [ 10, 11].
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An increase in permeability in normal-appearing white matter of 0.1 ml/100 g/min increased the risk of multiple sclerosis 8.5 times whereas having more than nine T2 lesions increased the risk 52.6 times.
For example, acute inflammation is associated with trauma, stroke and encephalitis, whereas multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis are some of those conditions involving chronic inflammation.
For example, we tagged Alzheimer's disease samples to AD1 whereas multiple sclerosis samples to MS1.
In summary, whereas multiple sclerosis is to a great extent an inherited trait, the familial relative risks may be lower than usually reported.
Clinical remission has been achieved in all patients with polychondritis (n = 1), SLE (n = 6) and multiple sclerosis (n = 2) whereas we observed progression of disease in all patients with SSc (n = 3) and panniculits (n = 1).
A significantly decreased SHR was also observed for Parkinson disease, whereas the SHRs for ALS and multiple sclerosis were close to unity.
Statins are already on the market, and if they work, patients will welcome them, because existing treatments for multiple sclerosis are only moderately effective and must be injected several times a week, whereas statins come in pill form.
He had multiple sclerosis.
Avonex treats multiple sclerosis.
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