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Krumbholz, M., Derfuss, T., Hohlfeld, R. & Meinl, E. B cells and antibodies in multiple sclerosis pathogenesis and therapy.
van Horssen, J., Witte, M. E., Schreibelt, G. & de Vries, H. E. Radical changes in multiple sclerosis pathogenesis.
Pro-inflammatory cytokines play a crucial role in the regulatory and effector phase of the immune-mediated mechanism sustaining multiple sclerosis pathogenesis (MS) thus supporting the use of anti-inflammatory cytokines as a therapeutic option.
A role for HLA-G in multiple sclerosis pathogenesis was first proposed based on the observation that sHLA-G levels were elevated in MS patients relative to healthy controls [34].
Much of our current knowledge about multiple sclerosis pathogenesis has been obtained from its animal model experimental autoimmune encephalomyelitis (EAE).
Much of the current understanding of multiple sclerosis pathogenesis has been obtained from animal models of the disease such as EAE.
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The autoimmune model of multiple sclerosis (MS) pathogenesis provided for many years a useful but incomplete conceptual framework for understanding the complex array of factors that lead to the loss of immune homeostasis, myelin and axonal injury, and progressive neurological symptoms.
Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis.
Ontaneda, D., Hyland, M. & Cohen, J. A. Multiple Sclerosis: New Insights in Pathogenesis and Novel Therapeutics.
Ben-Nun, A. et al. From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development.
are to be congratulated on the application of cutting edge cell and molecular biologic techniques to address central issues regarding the immune-pathogenesis multiple sclerosis (MS) of lesions. 1 This was a demanding study with regard to acquisition of patient material, experimental design, quality and quantity of labor involved, and cost.
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