Sentence examples for multiple sclerosis onset from inspiring English sources

Guillemin, F. et al. Older age at multiple sclerosis onset is an independent factor of poor prognosis: a population-based cohort study.

While results of published studies on the association between pregnancy and SLE are contradictory [5], [6], evidence suggests that the risk of multiple sclerosis onset is reduced during gestation and increased in the first 6 months after pregnancy [7], [8].

Thus, there are positive effects of smoking cessation on disease progression even after multiple sclerosis onset.

These comprised gender, age at multiple sclerosis onset and relapse history (relapses within the first 2 years, and residual deficit after the first relapse).

> -wrap-foot> In summary, the disease phenotype at multiple sclerosis onset was found to be correlated not only with age at onset, but also with the disability progression.

There is considerable age specificity for multiple sclerosis onset with a peak at age 24 years and a mean age of 30 years in most series (3).

To assess the relationship between disease progression and the phenotype at multiple sclerosis clinical onset, we separately examined relapsing onset and progressive onset multiple sclerosis with respect to the time to reach the two disability milestones (DSS 3 and DSS 6) from multiple sclerosis clinical onset (i.e. disease duration) or from birth (i.e. age).

On the contrary, the median durations from multiple sclerosis clinical onset to both DSS 3 and 6 were significantly shorter in progressive onset multiple sclerosis than in relapsing onset multiple sclerosis (DSS 3: 2.0 versus 10.0 years, respectively, P < 0.0001; DSS 6: 10.0 versus 21.7 years respectively, P < 0.0001).

During the follow-up, 618 patients with relapsing onset (38.4%) had converted to secondary progressive phase, after a median time from multiple sclerosis clinical onset of 16.0 years (14.7 17.3) and at a median age of 40.4 years (39.3 41.4).

In the same line, although the follow-up duration from multiple sclerosis clinical onset was similar in males and females (13.3 ± 8.8 years and 12.6 ± 9.7 years, respectively, P = 0.119), males had more frequently reached both disability milestones than females (DSS 3: 76.6 versus 66.5%, respectively, P < 0.0001; DSS 6: 42.5 versus 31.7%, respectively, P < 0.0001).

Although males and females had the same age at multiple sclerosis clinical onset (median 30.2 years, P =0.784), males were significantly younger than females when they reached the two disability milestones (DSS 3: 40.4 versus 42.7 years, P <0.0001; DSS 6: 49.7 versus 52.2 years, P <0.010; Fig. 2).