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Dr. Reingold emphasized that the study did not continue long enough to show that Avonex prevents multiple sclerosis, only that the drug delays it.
In contrast, most patients with multiple sclerosis only suffer from specific defects of their peripheral B-cell tolerance checkpoint that likely result from abnormal regulatory T cells, which normally control this second B-cell selection step in the periphery.
Thus far in its development for the treatment of multiple sclerosis, only meeting abstracts covering one study have been reported.
The human gene BDNF genotyping 196G/G carriers can increase the risk of multiple sclerosis only in females, but not in males [ 31].
For example, in a mouse model of multiple sclerosis, only females exhibit neuropathic pain (sensitivity to mechanical, cold, and heat stimulation), even when motor dysfunction does not differ between the sexes [ 141].
In contrast to prior studies suggesting that acute episodes of tumefactive IDD are usually isolated and rarely progress to more typical multiple sclerosis (Kepes, 1993), we found that the majority (70%) ultimately developed clinically definite multiple sclerosis, only a very small subset remaining isolated at last follow-up.
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B-cell effector function may be important for predicting response to BCDT, as anti-CD20 therapy was successful in an animal model of multiple sclerosis but only if B cells secreting IL-6 were contributing to pathology [ 5].
Initial MRI lesion number and volume predicted conversion to clinically definite multiple sclerosis but late disability only modestly (Fisniku et al., 2008; The Optic Neuritis Study Group, 2008).
Collectively, this represents a major advance for not only multiple sclerosis, but also other neurodegenerative diseases characterized by a demyelinating component.
In grey matter, a number of sterols were decreased in active-multiple sclerosis, but only one sterol was decreased compared with control in inactive-multiple sclerosis.
Statins are already on the market, and if they work, patients will welcome them, because existing treatments for multiple sclerosis are only moderately effective and must be injected several times a week, whereas statins come in pill form.
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