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Numerous studies in animal models for multiple sclerosis, namely experimental autoimmune encephalomyelitis (EAE), have provided direct and univocal evidence that autoreactive Th1/Th17 cells are generally orchestrating a coordinated attack of the immune system on the CNS (1, 2).
Immunomodulatory treatments for relapsing-remitting multiple sclerosis, namely glatiramer acetate and the β-interferons, provide a marked reduction in relapse rates and in MRI markers of disease activity [ 21].
Moreover, human MSCs migrated in response to chemokines known to be expressed in the lesions of multiple sclerosis, namely, SDF-1, MCP-1, RANTES, MIP-1 α, and IP-10 [ 72], and to IL-8 which is highly expressed in gliomas [ 82].
Its broad spectrum of action renders fingolimod a possible candidate for further research in other forms of multiple sclerosis, namely primary progressive multiple sclerosis and secondary progressive multiple sclerosis, in which inflammatory activity is less pronounced, and benefit may be derived from its neuroprotective effects.
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In the second part we review the current literature available on a selected subset of diseases, namely, dementia, schizophrenia, multiple sclerosis and others, and try to extract for each disease the common findings and main differences between reports.
The involvement of Fas in tissue damage has been shown in other tissue-specific autoimmune diseases, namely autoimmune thyroiditis, multiple sclerosis, and insulin-dependent diabetes mellitus.
This chapter illustrates this transformation through three classical neurological diseases, namely, acute ischemic stroke, multiple sclerosis, and brain tumors.
A SNP, namely the A168G polymorphism in the type III promoter of MHC2TA, was recently associated with RA, multiple sclerosis and MI.
Avonex treats multiple sclerosis.
She had multiple sclerosis.
It is multiple sclerosis, not muscular sclerosis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com