Sentence examples for multiple sclerosis experimental from inspiring English sources

A novel antigen-specific therapy has been developed which, when administered semi-therapeutically, is highly efficacious in the treatment of the mouse model for multiple sclerosis, experimental autoimmune encephalomyelitis (EAE).

The ability of microbial TLR ligands to trigger disease onset in experimental models of arthritis, multiple sclerosis, experimental allergic encephalomyelitis, myocarditis, diabetes and atherosclerosis have also been reported.

Further, PEGLA had no effect in an animal model of multiple sclerosis, experimental auto-immune encephalomyelitis, suggesting PEGLA cannot target the central nervous system.

Evidence for mitochondrial dysfunction in multiple sclerosis outside the context of LHON has also been observed in functional imaging studies [5], pathological analyses [2], [6], [7] and in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) [8].

In a murine model for multiple sclerosis (experimental autoimmune encephalitis), Th cells that recognise a myelin autoantigen and produce IL-17, IL-22, CXCL10, CCL2, and CCL5 induce disease upon adoptive transfer into recipients.

In the study conducted by Ziehn and colleagues, it was found that testosterone could restore the excitatory synaptic transmission and the levels of both pre- and postsynaptic proteins in a mouse model of multiple sclerosis (experimental autoimmune encephalomyelitis, EAE) [ 46].

Using this approach, we demonstrate that antigen persistence is a dominant factor governing the elicitation of tolerance in the model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), induced by immunizing B10.PL mice with the N-terminal epitope of myelin basic protein.

The findings introduced in this article show that TCR associated with the development of multiple sclerosis and experimental autoimmune diseases including encephalomyelitis (EAE), neuritis (EAN) and carditis (EAC) are identifiable by complementarity-determining region 3 (CDR3) spectratyping analysis and subsequent sequencing of the CDR3 region of spectratype-derived TCR clones.

Similar effects have been widely investigated for multiple sclerosis and experimental autoimmune encephalitis and support the role of MSC treatment by modulation of T-cell response [58].

This antagonistic property was translated into an anti-inflammatory effect in a murine model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), in which its administration before disease onset significantly reduced clinical symptoms [21].

This locus of approximately 3Mb in length was found to be associated with the murine model of multiple sclerosis EAE (Experimental Autoimmune Encephalomyelitis), displaying maximum LOD scores in the range 4.5 to 5.8, depending on the EAE phenotype.