Sentence examples for multiple sclerosis conversion from inspiring English sources

Information on multiple sclerosis conversion was acquired from hospital records 2 years after optic neuritis onset.

Future prospects after optic neuritis are still very diverse, which merits further studying of potential biomarkers of multiple sclerosis conversion such as MRI permeability.

We found that permeability in both normal-appearing white matter and in the thalamus provide novel information on multiple sclerosis conversion, when compared to using T2 lesions alone.

Logistic regression analysis showed that baseline permeability in normal-appearing white matter significantly improved prediction of multiple sclerosis conversion (according to the 2010 revised McDonald diagnostic criteria) within 2 years compared to T2 lesion count alone.

> -wrap-foot> In this study of a prospective cohort of optic neuritis patients we found that BBB permeability measured by DCE-MRI in periventricular normal-appearing white matter and the thalamus provides prognostic information about multiple sclerosis conversion after 2 years.

In an attempt to evaluate if permeability would be of any use in a clinical setting, we excluded these six patients from the data set and found that permeability in normal-appearing white matter (P = 0.027) and CSF leucocyte count (P = 0.023) were now significant predictors of multiple sclerosis conversion with Nagelkerke R2 = 0.64 and P = 0.001.

Comabella, M. et al. Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis.

A threshold of permeability in normal-appearing white matter >0.13 ml/100 g/min predicted conversion to multiple sclerosis with a sensitivity of 88% and a specificity of 72%.

On the other hand, those with many white matter lesions were frequently initiated in immunomodulatory treatment, presumably delaying conversion to multiple sclerosis.

show that MRI measures of blood-brain barrier permeability improve prediction of conversion to multiple sclerosis within 2 years, compared to T2-lesion count alone.

Receiver operating characteristic (ROC) curves were used to estimate the ability of a risk factor to predict conversion to multiple sclerosis and establish a cut-off value providing the best combined sensitivity and specificity.