Exact(3)
Thus, CD4+ Tregs or CD8+ Tregs appear impaired in number and/or function in diverse autoimmune diseases [ 98] such as lupus erythematous, autoimmune diabetes, rheumatoid arthritis, myasthenia gravis, multiple sclerosis, allergy, inflammatory bowel disease, hepatitis C, herpes simplex, HIV infections, and cancer.
Adoptive transfer of antigen-specific Tr1 cells has been shown to be efficacious in suppressing inflammation in a variety of animal models for chronic inflammatory and autoimmune diseases, such as colitis, type 1 diabetes, multiple sclerosis, allergy and transplantation [ 20, 24- 28].
Other molecular mechanisms may explain the role of vitamin D in cardiovascular diseases, diabetes mellitus, cancer, multiple sclerosis, allergy, asthma, infection, muscle weakness, depression, etc., Several studies found association between low vitamin D levels and hypertension, coronary artery calcification, heart disease and several cancers.
Similar(57)
Prospective clinical studies of multiple sclerosis and allergy showed the importance of both pleiotropic and disease specific modules for clinical stratification.
Moreover, the pleiotropic or disease-specific modules could be used to stratify patients in prospective clinical studies of multiple sclerosis and allergy.
12 23 The progressive increase of suicide risk with recency of being diagnosed or treated for physical illnesses has been reported in a number of studies on specific physical conditions such as cancer, 14 26 diabetes, 27 multiple sclerosis, 28 allergy 24 as well as other physical illnesses.
Greaves argues there is a similar story at work in the prevalence of type 1 diabetes, Hodgkin's lymphoma, multiple sclerosis and allergies in wealthier countries: "The problem is not infection.
Levinson is focusing on research into diseases where the immune system goes wrong, like rheumatoid arthritis, multiple sclerosis and allergies.
The inappropriate activation or suppression of T cells can be implicated in nearly all human diseases, including cancer, heart disease, multiple sclerosis, asthma, allergies, diabetes, and many others [3], [4], [36], [37], [38].
Low incidence of RA has been reported in developing countries, where the helminth infection rate is higher [ 28, 29], but in contrast to the inverse correlation described for other autoimmune diseases, such as type 1 diabetes and multiple sclerosis, or allergies, the relationship between human RA and the presence of helminths has not been well defined [ 30– 30].
Other autoimmune diseases such as multiple sclerosis [ 41], allergy [ 42], rheumatoid arthritis [ 43], systemic lupus erythematosus in US [ 44], but not in UK [ 45] have shown similar spatial patterns.
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