McNemar's tests indicated four genera were also enriched in urine prior to adjustment for multiple sampling in this group: Pelomonas (p = 0.003, FDR = 16.70%), Propionibacterium (p = 0.004, FDR = 19.18%), Staphylococcus (p = 0.023, FDR = 60.69%), and Finegoldia (p = 0.023,FDR = 60.69%).
Combining data from multiple samples masks this variation.
By comparing multiple samples against this standard, a larger number of samples can be probed.
The cause of outliers was probably due to mixing up of specimen tubes or contamination of samples resulting from unfamiliar handling of multiple samples, although this was not easily determined [ 15, 16].
Multiple sampling methods may limit representativeness of this cohort, and hence the generalizability of these findings.
This technique enables rapid multiple sampling of the analysed material, such as needed for mapping or in-depth profiling applications.
This was also supported by our multiple sampling cross-validation analysis.
This makes SynTReN unsuitable to evaluate the use of multiple sampling to discard non-significant gene-pairs.
This can be easily performed when using the vial for multiple sampling.
The AROR peaks were generally robust in multiple sampling experiments (see Materials and Methods).
