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One common approach has been to screen multiple rodent strains for exercise capacity, followed by quantitative trait loci (QTL) analyses to identify loci linked to exercise capacity.
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However, epitopes of closely related rodent strains show only minor variations affecting the production of specific discriminating antibodies.
Hantavirus enzootics are maintained in multiple rodent species [5] [8].
In long lived rodent strains and in humans, lifespan is often limited by spontaneous tumorigenesis.
For example, baseline neophobia or anxiety is greatly reduced during domestication of laboratory rodent strains.
Third, metformin prevents cancer and extends the lifespan of cancer-prone rodent strains.
Rodent strains vary in their susceptibility to low-dose BPA exposure (Richter et al. 2007).
Inorganic mercury (iHg) is known to induce autoimmune disease in susceptible rodent strains.
Some specific rodent strains are highly prone to spontaneous mammary tumor formation.
Both rodent strains examined have low background rates and very little variability between control groups.
Moreover, metformin can also prolong lifespan without affecting cancers in non-cancer-prone rodent strains [ 36- 41].
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