This factor also contributed to mortality in four out of the five multiple high-risk categories.
Within multiple high-risk categories, only the category combining late birth with high parity birth recorded a slight significant decrease in rate (−2.0 percentage points) during this period.
Each delivery was assigned exclusively to 1 of 6 risk categories: (1) multiple gestation, (2) fetal malpresentation, (3) delivery at <36 weeks' gestation, (4) not suitable for trial of labor, and (5) term delivery (≥36 weeks' gestation) with medical complications, and (6) term delivery (≥36 weeks' gestation) without medical complications.
Given the need to assess two vaccines, three risk categories, and multiple vaccination age points in this economic analysis, many options were considered for defining a reasonable set of vaccination strategies that are both clinically relevant and practically implementable.
Within the multiple high-risk category, the most common combination was late birth (mother's age >34) combined with short birth spacing (13.8% of births), followed by the combination of short birth spacing with high parity birth (4.8%).
Hierarchical risk exposure categories (including mutually exclusive categories with a single, or multiple risk exposures) were constructed for participants testing at the two sites and compared using Fisher's exact test.
Figure 1 demonstrates the prevalence of the different HPV risk categories, including cases of single and multiple HPV infections, with or without coinfections by HPV types belonging to other risk categories.
A little more than half referred to the use of condoms sometimes with a similar distribution in the multiple partners (49.4%) and HIV-1 positive partner (43.9%) partner risk categories.
However, because vertebral fracture is associated with multiple risk factors, stratified models were used to estimate the fracture risk in four categories of exposure and the heuristic approach described by Hanley, J.A. [ 31] was used to calculate the PAR.
