Sentence examples for multiple retrospective trials from inspiring English sources

The effect of surgery on macrometastases has been an unresolved issue addressed in multiple retrospective trials studying the impact of removal of the breast in patients with stage IV disease at presentation [ 52, 53].

In general, candidate predictive biomarkers are often identified initially by multiple retrospective analyses of clinical trials, and a predictive signature is subsequently developed and evaluated in Phase II trials to be used in Phase III trials.

The validation phase of gene-expression signatures is very time-consuming and costly because it requires either multiple retrospective studies with large sample sizes or prospective clinical trials.

The efficacy and excellent safety profile of ECP has been shown in a large number of retrospective trials.

Most of them were non-randomized, retrospective trials and reported conflicting results.

There is a wide range, from 0.014 to 0.45%, produced by meta-analyses mainly based on retrospective trials.

In human retrospective trials, the APRV methodology used was not consistent among the studies analyzed (Table 3).

Observational data and retrospective trials have been referenced where appropriate.

Multiple retrospective and prospective studies have been published recently, defining these risks.

Multiple retrospective series, 19– 25 and two observational prospective studies are available.

Since then, multiple retrospective series have been published that support these favourable factors [32,36,37] (Table 1).