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Multiple retrospective studies do, however, support the role of radiotherapy or chemoradiotherapy, although the benefits seem modest.
Data from multiple retrospective studies support that PET-defined response at end of treatment correlates with outcome in DLBCL.
Multiple retrospective studies [ 10- 12] have reported that prognosis is poor among these patients, which could result from the lack of therapeutic options or inherent tumor aggressiveness [ 9].
In multiple retrospective studies, chemoradiation therapy has been shown to confer a survival advantage compared with surgical resection alone [ 2, 7, 8].
Multiple retrospective studies have demonstrated that EAC detected by endoscopic surveillance has lower staging with superior survival than EAC discovered without surveillance.
The validation phase of gene-expression signatures is very time-consuming and costly because it requires either multiple retrospective studies with large sample sizes or prospective clinical trials.
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In conclusion, multiple small retrospective studies with many treatment arms did not find any difference in one treatment over another or no treatment at all in correcting the INR of those patients with WAICH [20, 21, 41, 42].
EFV has been associated with significantly decreased virological failure relative to NVP in multiple large retrospective studies, including a large South African study of 2817 subjects, and 2 studies in the United States and United Kingdom containing a total of 1414 subjects [ 39– 41].
The effect of surgery on macrometastases has been an unresolved issue addressed in multiple retrospective trials studying the impact of removal of the breast in patients with stage IV disease at presentation [ 52, 53].
Multiple retrospective and prospective studies have been published recently, defining these risks.
There are multiple observational and retrospective studies comparing the clinical efficacy of nevirapine and efavirenz based ART in HIV/TB co-infected patients; however, results of this study were found contradictory to those [ 9, 14- 16].
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