Intra-clade analyses were less consistent but nevertheless yielded multiple reliable results, such as a significant phylogenetic signal in CVA for Bufo and Hylinae, in logDF for Hylinae and Rana, and in logSF for Bufo.
Many similar immune cell gene sets are seen, along with multiple non-specific results such as cancer gene sets.> -wrap-foot> *Poritive or negative correlation between module and phenotype.
However, methods for dealing with missing data to achieve unbiased statistical results, such as multiple imputation or doubly robust estimators, are increasingly widely used, and these rely on models that effectively predict missing data.
Related to the high dropout and low retention rates is the fact that no 'state of the art' analyses could be used to analyze the results, such as multiple imputation (MI).
So while multiple factors are required to advance preclinical results such as these into clinical practice, we believe that our work serves as proof of principle that model simulations, incorporating clinically relevant genetic and protein biomarkers, can be employed to advance the vision of precision medicine in oncology.
Results such as these might be further improved when multiple proteins, such as Aβ and tau, and multiple neurotoxic pathways are concurrently targeted.
Severe sepsis, an example of a complex trait, results from multiple etiologies, such as Gram-positive and Gram-negative bacteria, or fungal infections.
For this reason, tools have been developed to employ multiple methods, e.g. DELLY (Rausch et al., 2012), LUMPY (Layer et al., 2014) and those that merge the results from multiple tools, such as SVMerge (Wong et al., 2010).
Results from multiple approaches such as the domain-based method, prediction with the GOA database, and analysis of the second layer neighbors could also be combined to produce a comprehensive prediction.
19 The reasons for this variability between institutions probably results from multiple factors such as number of prescriptions and treating physicians, different approaches to drug prescriptions between physicians (ie, strict adherence to guidelines or a more permissive or individual approach, as well as from economic restrictions).
