Sentence examples for multiple resistance pathways from inspiring English sources

Spaans et al. [ 42] suggested that a combination targeted therapy that simultaneously inhibits multiple resistance pathways would elicit a better clinical response.

The molecular mechanisms behind the evolution of spontaneous antimicrobial resistance in B. cenocepacia are not known and how the multiple resistance pathways function on a global scale to allow B. cenocepacia to survive antibiotic therapy is poorly understood.

Its genome encodes multiple antimicrobial resistance pathways and it is not known which of these is important for intrinsic or spontaneous resistance.

Although the reason why the single bortezomib regimen is not significantly active in clinical trials might be explained by the possibility of the activation of multiple drug resistance pathways in heavily pretreated populations, particularly those previously exposed to anthracycline [ 16], alternative mechanisms might also confer sensitivity to bortezomib in patients with breast cancers.

But the ability of solid tumors to develop multiple salvage and resistance pathways that allow them to circumvent inhibition of a single signaling pathway is becoming increasingly evident [ 98].

Moreover, novel studies performed in animal models, breast cancer cells (Lu et al, 2003; Wang et al, 2009; Boyer et al, 2012) and human tumours (Nagata et al, 2004; Liang et al, 2010; Zhang et al, 2011) have suggested Src as a key modulator of trastuzumab response and a common node downstream of multiple trastuzumab-resistance pathways.

Considering this apparent plasticity in the molecular processes leading to induced resistance against M. oryzae, it is tempting to speculate that rice is endowed with multiple blast-effective induced resistance pathways.

Additional miRNA pathways involving targets other than BCL-2 have also been shown to influence tamoxifen response of breast tumor cells (5, 6) further underscoring the potential complexity of miRNA regulation of multiple non-overlapping endocrine resistance pathways.

These results suggest that acquired resistance to a chemotherapeutic agent could have activated general resistance pathways that impart resistance to multiple agents, including irradiation.

The use of potent therapies inhibiting critical oncogenic pathways active in epithelial cancers has led to multiple resistance mechanisms, including the development of highly aggressive, small cell neuroendocrine carcinoma (SCNC).

Approaches to accurately and reproducibly measure multiple nodes in a pathway should allow identification of a tumor's oncogenic pathway addiction as well as highlight potential activated resistance pathways that may result in poor, or limited, response to therapy.