Sentence examples for multiple resistance factors from inspiring English sources
Selection of empiric antimicrobial therapy must consider the likelihood of encountering isolates that possess multiple resistance factors (e.g., extended-spectrum beta-lactamases [ESBLs], vancomycin-resistant enterococci [VRE]) [ 1, 2].
New β-lactamases that are transferred among species on plasmids with multiple resistance factors are also being described as a continuing exercise.
Because frequently recovered isolates may possess multiple resistance factors (eg, extended spectrum beta-lactamases [ESBLs]) that express antimicrobial resistance, empiric antimicrobial therapy should have anticipated activity against these difficult-to-treat isolates [ 1, 5].
These strains, which also showed resistance to other antimicrobial agents (ampicillin, streptomycin, gentamicin, tobramycin, netilmicin, tetracycline, and sulfamethoxazole), may be attributed to multiple resistance factors present on transmissible genetic elements (15).
The therapeutic principle that emerges from these findings is that simultaneous removal of multiple resistance factors is required to overcome TRAIL resistance and to efficiently kill cancer cells by TRAIL-comprising therapeutic combinations.
Based on the presence of multiple tellurite resistance factors, a new metal resistance (tellurite) was identified and confirmed in Frankia.
The in silico analysis of the V583 genome sequence has also revealed the presence of EF0031 gene, whose product shares 24% identity and 45% homology with MprF (multiple peptide resistance factor) of S. aureus.
Because the resistance was incompletely recessive and involved multiple factors [ 65], the F1 progeny were randomly mated to obtain recombination of resistance factors in the F2 progeny to allow selection of resistant genotypes.
Where are these resistance factors coming from?
Solvent tolerant microbes employ multiple resistance mechanisms.
Although Mcl-1 has emerged as a significant cancer cell survival and therapy resistance factor across multiple cancer indications, it is now widely recognized that capturing the therapeutic benefit of Mcl-1 antagonism will likely rely on rational synthetic lethal strategies [ 1].
