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Filaggrin is extensively deiminated at multiple residues in the early corneocyte [8].
This suggests a strong possibility of involvement of multiple residues in the activation process of PknJ.
These results suggest the involvement of multiple residues in PknJ dimerization.
Concordantly, mutation of multiple residues in the tail domain preventing Aurora B phosphorylation in vivo produced robust kinetochore MT attachments, whereas mutation in these residues mimicking constitutive phosphorylation resulted in loss of interaction [24], [57].
These findings point to multiple coevolutionary events between multiple residues in proteins which make it different from the coevolution between, for example, hydrogen bonded base pairs in RNA [16].
We were able to identify multiple residues, in which disease-causing mutations have been identified (Table 1).
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Substitutions in both single and multiple residues resulted in NarQ proteins that were inactive and ligand insensitive, a "locked-off" phenotype.
In summary, we have identified multiple residues involved in forming high affinity binding site for Kv1.5 blockers.
In addition, position 446 has multiple residues observed in neutralized variants (K,N,S,R) and it appears not to affect antibody binding.
Multiple residues prevailed in the bee, pollen and wax samples, with 2 or more pesticides detected in 92.3% of 749 analyzed (Table 4).
Here, multiple residues lay in close proximity forming hydrogen bonds with AR-C155858 (Table 1).
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