Yao, L., Cengic, I., Anfelt, J. & Hudson, E. P. Multiple gene repression in Cyanobacteria using CRISPRi.
We propose that the use of multiple modes of repression ensures inactivation of nos RNA that is translated at earlier stages of oogenesis and maintenance of this inactivate state throughout late oogenesis into embryogenesis.
The student protests of the 1960s were a form of Great Refusal, a saying "NO" to multiple forms of repression and domination.
Multiple modes of repression could allow Gro to fine tune gene activity in response to promoter context and cellular environment.
Since SUMO modification participates in the regulation of multiple protein functions, repression of sumoylation may mediate a number of NO-related cellular events and pathological processes.
In summary, N-Bak mRNA translation seems to be controlled via multiple mechanisms, including repression by uORF, premature termination context and also potentially by miRNAs.
Moreover, different ISGs function additively or synergistically to interfere with HCV infection, indicating that the combinatorial and concerted actions of multiple effectors mediate repression of HCV replication.
In contrast to previous models [ 25, 31], we consider dimerization, complex formation, multiple modes of repression, and active degradation of the toxin and antitoxins; these processes are modeled based on the physiological findings from experimental studies (Methods).
Thus, the four genes, as expected, are required for repression of multiple targets by multiple miRNAs.
