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The inclusion of an experimental neoantigen was dictated by multiple reports showing that tumors naturally produce antigenic epitopes derived from mutant as well as native proteins.
There are multiple reports showing beneficial effects of both esculetin [47] and CAPE [50,71 73] in vivo, although only CAPE has shown positive effects in the CNS.
In addition, there are multiple reports showing the safety of plant administration in experimental animals at around 4 times higher doses than the highest dose tested in this study [ 32, 33].
This is consistent with multiple reports showing that mutation of the conserved "arginine finger" within the GAP domain decreases neurofibromin GAP function while leaving the domain structurally intact (Ahmadian, 1997; Scheffzek, 1997; Klose, 1998; Hiatt, K., 2001).
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Although postoperative radiotherapy (RT) for malignant pleural mesothelioma (MPM) has historically been delivered using 3-dimensional confoRTal RT (3DCRT) techniques, multiple reports show noteworthy safety and efficacy of the more advanced intensity-modulated RT (IMRT).
Multiple reports show that in Colorado, teen drug use and crime are both down.
The Texas health system was put under the microscope in August after multiple reports showed that its maternal mortality rate has doubled in recent years.
Multiple reports show that TGFβ stimulates autophosphorylation-dependent activation of focal adhesion kinase (FAK) [23], [55].
Multiple reports showed that mutation of the conserved 'arginine finger' within the GAP domain decreases neurofibromin GAP function while leaving the domain structurally intact (Ahmadian et al., 1997; Scheffzek et al., 1997; Klose et al., 1998; Hiatt et al., 2004).
Multiple reports show a decline in seminal volume, motility and morphology with increasing paternal age (Dondero et al., 1985; Centola and Eberly, 1999; Kidd et al., 2001; Eskenazi et al., 2003; Hellstrom et al., 2006; Stone et al., 2013).
The Dell committee argued that such a plan was fraught with risk, pointing to multiple internal reports showing the company suffering further if it remained public.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com