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This scenario is best exemplified by troglitazone (Rezulin®), which was ultimately withdrawn from the market in 2000 due to multiple reported cases of acute liver failure [ 11].
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Our results from monitoring one site throughout the hibernation period over two consecutive years as well as reported cases from multiple sites in multiple years show that bats with fungal growth are first seen in January, the number of cases slowly increases into February and peaks in March, then in April when bats emerge from hibernation it drops again.
A recent publication reports on another WAS patient with multiple somatic alleles [30], and thus, the brothers described here are the second and third reported cases of multiple somatic alleles in WAS.
It was suspected that IVTA injections and topical steroid use could weaken the zonules, as two of the five reported cases had multiple IVTA injections.
The 182 reported cases include multiple distinct spatiotemporal clusters and 32 identified infections in health care workers (3 ).
An extensive literature review from Abdel-Wanis [ 23] revealed 13 reported cases of multiple simple bone cysts before 2001.
Multiple symptoms, signs, and clinical diagnostic data were common to the first 10 reported cases.
To the best of our knowledge, this is the first reported case of multiple dermoid sinuses of two different types in the head of a Saint Bernard dog.
HUS surveillance is complicated by the lack of a single diagnostic test and the need for multiple data elements to validate each reported case.
In instances where there were multiple, individual case safety reports for the same identification number, we selected the earliest reported case.
Additionally, we noted a significantly higher number of multiple births reported among cases compared to controls (8.4 % among the cases; 4.0 % and 3.8 % among the interviewed and birth certificate control groups, respectively).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com