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Clinicians cannot rely upon multiple replicate observations, and their measured variance, to assess the random component as can be done in the animal laboratory.
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This was achieved by incorporating GP and NBD with corresponding prior information into the HMM for each gene, allowing samples having either multiple replicates or single observations.
Finally, replication is a key consideration in any experiment, and especially in experimental evolution, where random genetic drift plays a large role: observation of a large allele frequency difference at a locus in multiple replicate experiments will increase confidence that the difference is due to selection at the locus rather than drift.
Replicate observations are used to determine the variability under the specific experimental conditions, and therefore, a true replicate must be obtained from a complete repetition of the experiment.
Multiple replicate chips were printed, each carrying all six conditions printed in multiple replicate spots.
Multiple replicate analyses of serum pool aliquots were performed.
from multiple replicate experiments.
Multiple replicate copies of the library were thus generated.
For each of the three regions, three replicate observations were obtained.
They may also explain our failure to replicate observations made in adult rats with hydrocephalus.
This permutation procedure maintained the structure of the data and the same variation in network metrics, but removed the link between observations of the same individual across multiple replicates.
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