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Tools such as HHRep [ 17] and PEPPER [ 18] efficiently address genome-scale search for multiple repeats in proteins.
Traditional gel blot hybridizations can hardly be used to analyze the organization and relative positions of multiple repeats in a genome.
Conservation of multiple repeats in diploid genotypes suggests presence of paralogs due to duplication of a particular locus within the genome.
The arrangement of multiple repeats in tandem generates a horseshoe-shaped solenoidal structure, with the β-strands stacking to form the concave surface and the variable stretches forming the convex surface [ 1, 5- 7].
It would be interesting to characterize the posterior HoxD cluster in limbless lizards and see whether there are overtly multiple repeats in the region though the Hox genes remain intact.
Since we do not know any other work that is a filter for multiple repeats, in particular with the same kind of output, we do not compare TUIUIU directly to other methods, but try instead to reproduce as much as possible the filtering conditions used by such approaches.
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The rule is subverted in A. baumannii BAPs, which feature multiple repeats varying in length, composition and relative arrangement.
Concerted evolution of repeats in turn suggests a mechanism by which a single non-synonymous mutation could rapidly spread to be present in multiple repeats, effecting a major change in the structure of the protein.
Assaying all possible protein interactions experimentally in several species, in multiple repeats and under different conditions remains an enormously expensive and time-consuming challenge.
A fixed number of cells was seeded in 96-well plates in multiple repeats.
Although the amount of 14-3-3 14-3-3 14-3-3ghtly reduced in the Chk1 knockdown in Fig. 1D, this was not observed in multiple repeats of the experiment, including Fig. 1F, and was thus likely a blotting defect.
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