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The number of repeats in a telomere determines the maximum life span of a cell, since each time a cell divides, multiple repeats are lost.
Can BubR1-Bub3 bind much more tightly to other MELT repeats or when multiple repeats are present?
(These are "pull-down" experiments, which tend to have an exaggeratedly all-or-none character, but the results seem OK to the unpracticed eye. But see the comment on Figure 2, above. Interaction properties of multiple repeats are not the sum of their individual properties, as Rosen and others have emphasized).
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Typical satellite sequences, consisting of multiple tandem repeats, were not identified.
The presence of multiple MELT repeats is an essentially invariant feature of Spc105/Knl1 in evolution (Cheeseman et al., 2004).
In the majority of loci where multiple STAR repeats were present, the spacer sequences were often identical or differed by 1 3 nucleotides resulting in tandem repeats of ~50 nucleotides.
A total of 70 R2R3-MYB genes as well as genes encoding three other classes of MYB proteins containing multiple MYB repeats were identified and characterised with respect to structure and chromosomal organisation.
The EGF domain, which often occurs as multiple tandem repeats, is widely distributed among extracellular proteins involved in adhesion, receptor-ligand interactions, extracellular matrix structure, determination of cell fate, and blood coagulation [ 27].
Multiple technical and biological repeats are necessary to minimize false identifications.
However, there is no scientific evidence or consensus as to whether a single surgical debridement is sufficient or whether multiple repeat procedures are necessary for optimal treatment.
Telomeres are composed of repeated segments of DNA, and multiple repeat segments are lost each time a cell divides.
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