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Multiple release profiles were achieved by loading gel with a combination of low and high steric hindrance molecules.
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More sustained and multiple stage release profiles could thus be also obtained.
"You can release multiple drugs with different release profiles.
Thus, in order to provide personalized therapy to individuals, who may optimally respond to distinct drug release profiles, multiple batches of liposomes would have to be manufactured possessing different release kinetics.
The purpose of this study was to develop and validate a screening method based on scintillation probes for the simultaneous evaluation of in vivo growth factor release profiles of multiple implants in the same animal.
This new platform for multi-drug localized delivery can be easily fabricated, tuned, and translated to a variety of implant applications where control over spatial and temporal release profiles of multiple drugs is desired.
Flexible technology platforms are attractive for industry by enabling the delivery of multiple drugs, dose strengths and release profiles as well as being acceptable for broader patient populations.
The pellets' drug release profiles were controlled by multiple independent variables at different time points (⩽24 h).
These demand drug delivery designs for one single drug, dual drug release systems and multiple release matrices in which the macromolecular structure allows for higher solubilization, protection and sequential or combined release profiles.
This strategy may provide more flexibility and convenience than the alternative of manufacturing multiple batches of liposomes differing in composition to cover a wide range of release profiles.
Figure 7 In vitro drug release profiles.
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