Sentence examples for multiple related sequences from inspiring English sources
Employing genetical genomics, we showed that this approach is valuable for elucidating interactions between genes that originate from complex families with multiple related sequences.
Comparative sequence analysis is one of the more reliable RNA structure prediction approaches as it exploits information of multiple related sequences to infer the consensus secondary structure.
However, PCR amplification and sequencing of amplicons from 8 of 9 single pHap families presented evidence of multiple related sequences in the genome of Williams 82.
However, prediction performance breakthroughs have been limited to short RNA sequences; improvements on the accuracy for longer RNA sequences have relied on multiple related sequences [ 15, 16], which are often not available, or profile based alignments [ 17, 18], which can only be effective for known structures.
The prediction of tertiary interaction motifs is difficult without multiple, related sequences that are usually not available.
Moreover, it can add multiple related sequences to specific positions in the tree and thus correctly accounts for their relatedness and shared insertion and deletion events (Fig. 2).
First, to find potential contact sites, align multiple related protein sequences and look for regions of high homology.
Thus, a more reliable approach is to use comparative analysis to compute consensus secondary structures from multiple related RNA sequences.
Whereas most previous studies have used single residue hydrophobicity plots for characterizing of these domains, PHDhtm utilizes a system of neural networks and the evolutionary information contained in multiple alignments of related sequences to predict the above.
Thus, it is considered that pre-breakup units in the deep-offshore basins of Iberia comprise multiple rift-related sequences whose distribution and relative thickness depends on local subsidence rates, on the diachronous northward-migration of rifting, and on the relative crustal stretching experienced by individual sub-basins.
Although a direct comparison is not fair we will see in the next experiment that the use of multiple related genomes as reference sequences improves the resulting layouts.
