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Mostly multiple regulatory targets were predicted e.g. miR 414 has been predicted to have almost 70 targets in stevia EST and nucleotide transcript library.
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We describe identification of multiple direct regulatory target genes of Sox10 through a procedure based on function and conservation.
Optimal selection of multiple regulatory genes, known as targets, for deletion to enhance or suppress the activities of downstream genes or metabolites is an important problem in genetic engineering.
Unlike currently available methods, block decoys allow rapid construction of chimeric decoys targeting multiple regulatory elements.
Resistance is less likely to arise if multiple regulatory pathways are being targeted at the same time.
Resistance is less likely to arise if multiple regulatory molecules are being targeted at the same time [ 86].
Still, in the normal DSXF or DSXM homodimers, OD1 forms the dimeric DNA binding unit, and OD2 regulates the sex-specific functionality of the protein by sex-specific interaction with the transcriptional machinery, or maybe by forming sex-specific regulatory structures by increasing DNA binding cooperativity when DSX binds multiple regulatory sites of its target genes [ 43].
Expression profiling of miRNAs and their targets indicated multiple regulatory functions in the phase transition.
As such, the components of the prothrombinase complex are targets of multiple regulatory mechanisms to terminate the production of thrombin.
BayMiR models the combinatorial effect of multiple regulatory miRNAs on a single target which is critical, as most mRNAs are likely to be targeted by multiple miRNAs (Additional file 9: Figure S4).
ZNF217 has been reported to physically interact with CtBP1/2 [ 7], an adaptor protein found in multiple regulatory complexes at both activated and repressed gene targets [ 5, 7, 8].
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