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This locus contains multiple regulatory sites that could potentially affect expression and functions of CD44, a cell-surface glycoprotein influencing immunologic, inflammatory, and oncologic phenotypes, or PDHX, a subunit of the pyruvate dehydrogenase complex.
Protein kinases are a prime example of an enzyme with multiple regulatory sites that are spatially separate, yet communicate extensively for tight regulation of activity.
As many protein kinases have multiple regulatory sites that are often kinase specific, these sites provide the opportunity to develop non-ATP competitive protein kinase inhibitors with potentially higher selectivity.
The present sex differences do not segregate according to this pattern of hormone-sensitivities seen in other species but species differences in hormonal regulation of genes are likely in light of multiple regulatory sites and and/or local abundance of transcription factors.
Multiple regulatory sites interacting with increased number of trans-factors can achieve increased network connectivity.
Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements.
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Similarly, there is still little understanding on how multiple regulatory binding sites within the same region function as a unit.
Currently, the effect of only a single splicing factor can be evaluated by the software, although the approach itself is generalizable to multiple regulatory binding sites.
This can often be attributed to instances involving multiple sites or multiple regulatory factors, which are not components of current splicing models.
Multiple genetic polymorphisms involving 5-HTT regulatory sites reportedly increase the vulnerability for developing mood disorders (reviewed in Cannon et al. 2007).
The RegPredict tool allows simultaneous analysis of multiple microbial genomes and integrates information on location of regulatory sites, gene orthologs, operon predictions, and functional gene annotations.
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