Sentence examples for multiple regulatory regions from inspiring English sources

Using chromatin immunoprecipitation assays, we showed that Gli2 bound to multiple regulatory regions in the Ascl1 gene, including promoter and enhancer regions during Gli2-induced neurogenesis.

To understand the combinatorial role of multiple regulatory regions to produce the highly specific pattern of INO expression we have investigated promoter regions of this gene in Arabidopsis.

Interestingly, the region of the Nav2 gene that is hypermethylated with age is intronic, contains multiple regulatory regions (including H3K4me1, H3K4me3, and H3K27ac) and may be a potential enhancer region.

Preservation of duplicate genes is believed to be a common fate, particularly for genes that contain multiple regulatory regions, and thereby multiple copies of genes are maintained in the genome [ 7- 10].

In conclusion, evidence reviewed above suggests that scenarios leading to transcriptional activation are likely to be flexible and to a degree stochastic, allowing for gene activation to be triggered from multiple regulatory regions, each containing one or more TFBSs.

Identifying imprinted DMRs in humans is complicated by species- and tissue-specific differences in imprinting status and the presence of multiple regulatory regions associated with a particular gene, only some of which may be imprinted.

The latter possibility is suggested by genome location analyses, which indicate that Nanog co-occupies multiple gene regulatory regions with Oct4 and Sox2 (Chambers & Tomlinson, 2009).

Soubry et al. demonstrated the presence of alterations in the methylation status at multiple imprint regulatory regions in children with obese parents, suggesting a preconceptional influence of parental lifestyle and nutrition on the programming of imprint marks during gametogenesis [ 166].

The biochemical function of Hairy is associated with long-range chromatin modifications, which endow this factor with the ability to interfere with multiple cis-regulatory regions, including activators bound over 1 kb distal to the Hairy binding sites.

Multiple molecular polymorphisms in regulatory regions of candidate genes are often associated with variation for complex traits.

Frequent epigenetic changes in malignant neoplasias are global hypomethylation and focal hypermethylation of multiple CpG island gene regulatory regions.