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Moreover, the context-dependent roles of miRNAs in the metastatic cascade often involve multiple regulatory loops.
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However, the synchronization mechanisms by which this collective behavior arises remains to be understood, even if individual clock cells are known to operate through biochemical networks comprising of multiple regulatory feedback loops [ 7- 11].
This probably explains why the control of EMT is mainly via multiple negative regulatory loops, such that lifting the suppression can allow the efficient execution of EMT.
Each of these transitions rely on signal cascades with multiple regulatory and feedback loops allowing both plasticity and cooperation during development.
MPs may be considered as both the cause and the consequence of inflammatory diseases through multiple amplification and regulatory loops affecting vascular cell functions.
Mammalian cells have multiple regulatory mechanisms to deal with perturbations in cellular homeostasis, including feedback loops and crosstalk between the major signaling pathways.
The network level regulation involving multiple regulatory mechanisms is beyond the concept of a simple feedback loop, linear conversion [ 8] or statistic model.
These regulatory loops serve as important motifs in functional networks and play critical roles in multiple biological processes, either in healthy states or diseases.
Barclays has had to pay multiple fines in multiple jurisdictions over the last few years for multiple regulatory failures.
"Instead you will have chaos … every innovator survives on the oxygen of multiple regulatory systems".
In summary, AP2/ERF TF presents multiple regulatory roles in angiosperm.
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