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Unlike currently available methods, block decoys allow rapid construction of chimeric decoys targeting multiple regulatory elements.
Dendorfer, U., Oettgen, P. & Libermann, T. A. Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.
Genes with critical cellular functions are frequently regulated through a circuit involving multiple regulatory elements that are brought within physical proximity by DNA folding.
In order to interpret the genetic variation that lies in these regions, it is essential to understand how multiple regulatory elements cooperate to control target gene expression.
However, they are not ideally suited to in vitro investigations into multi-transcription factor-mediated processes that may require multiple regulatory elements to be inhibited in varying combinations.
We address this goal through functional studies of the mechanisms by which multiple regulatory elements collude to define gene expression and by utilizing 3-dimensional DNA organization to evaluate patient genetic data.
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Post-transcriptionally, 3'UTRs are known to contain multiple regulatory sequence elements important for gene regulation [ 13].
Transcriptional activation in higher eukaryotes frequently involves cooperative action of multiple regulatory DNA elements located at distant places [ 18, 19].
Schoenborn, J.R. et al. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ.
Four tolC promoters have been described in E. coli, suggesting the involvement of multiple transcriptional regulatory elements in response to different environments [33].
RGS14 is an RGS protein with multiple signaling regulatory elements, as it contains an RGS domain, tandem RBDs (Ras-binding domains), and a GoLoco motif [10], [11].
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