These commonalities are important in complying with multiple regulations and for understanding regulations in general.
In most cases, service sectors support multiple regulations to comply with government and industry regulations.
Thus, these data underscore the importance of the CD44 cytoplasmic domain in the function of the extracellular portion of CD44H, and demonstrate a role for ligation of human CD44 isoforms at multiple distinct sites in regulation of expression of CD44 binding to HA.
Although multiple regulatory proteins can also form a complex and the complex can regulate a target gene via a single binding site, we only consider regulation via multiple binding sites, the single binding site case being similar with our previous analysis.
We call this pattern differential regulation, which means that a gene with multiple binding sites for a number of miRNAs can be regulated by discrete miRNAs in differing cells under different conditions.
On the other hand, strategies such as CTLA4-Ig (CTL antigen 4-immunoglobulin), which specifically target a T-cell-dependent pathway, are effective because they probably confer desirable immuno-regulation on the multiple sites of T-cell action.
While it is obvious that deletion of an SP1 transcription factor binding site could result in down regulation of Cox-2 as in the case of allelic variant 1 there is also justification that the insertion of multiple SP1 sites could also result in down regulation (allelic variants 2 and 3).
Our model explains the role of multiple phosphorylation sites, compared to a single site, in the regulation of protein degradation.
This idea is supported by the fact that C/EBPβ has multiple phosphorylation sites, some of which are involved in the regulation of DNA-binding activity [16], while others are key determinants of its transactivation capacity [17].
The presence of multiple binding sites for the same transcription factor can facilitate regulation of gene expression by increasing transcription factor binding affinity and providing functional redundancy [ 42].
