Although critical genes for the regulation of fatty acid metabolism and/or energy metabolism such as Scd1, Acc2, Dio2 and Lepr were differentially expressed in KRAP−/−-BAT or liver, other multiple KRAP-regulated pathways and the interplays of these in vivo should be considered for potential mechanisms underlying the metabolic phenotypes in KRAP−/− mice.
Recent studies have indeed found multiple NO-regulated pathways within C. reinhardtii, including copper stress response, hypoxia, and ammonium and nitrate transport.
In this respect, herbal cocktail which contains various phytochemicals targeting multiple dys-regulated pathways in cancer cells may provide an alternative/complementary way to treat cancers.
Chinese herbal cocktail which contains various phytochemicals may target multiple dys-regulated pathways in cancer cells and thus may provide an alternative/complementary way to treat cancers.
Deeper analysis of the specific pathways showed, pathways with multiple regulated features including sterol/steroid biosynthesis with 10 genes down-regulated in fish fed FO (Fig. 5).
The differentially regulated pathways, upstream regulators, and functions are shown.
Because peroxisome proliferators can affect multiple signaling pathways by transcriptional activation of PPAR-regulated genes, it is likely that alterations in specific regulated pathways (e.g., suppression of apoptosis, protooncogene expression) are involved in tumor induction by peroxisome proliferators.
Thus, we speculated the regulated pathways of the momentous gene sets based on ToppFun, a web server for comparative enrichment analysis of multiple gene lists [ 19].
By using several independent procedures we identified multiple 1,25(OH 2D-regulated pathways and mechanisms that may disrupt the prOH 2D-regulatedinogenesis in vivo.
Analysis of regulated pathways was performed using Genemap software.
