Our structural studies show that CR3 is flexible and can adopt multiple orientations and multiple registries in the closed conformation.
25 The strengths of our study are: (1) its population-based design; (2) the large sample size of over 20,000 PC patients; (3) the comprehensiveness of the Danish medical registries together with the ability to link data across multiple registries; and (4) the nature of the uniform health care system in Denmark that ensures equal access to free health care to all residents.
The CPR number enables linkage of data from multiple registries, and thereby the collection of data at the individual and familial levels, unambiguously and without double-counting.
Some countries such as the United States contributed multiple registries including a race-specific registry in the Los Angeles area, and data from the multi-state SEER program.
Further strengths include the integration of multiple registries, allowing all-cause hospital admission rates in young people with diabetes to be investigated, and the use of multilevel Poisson models to appropriately account for clustering within matching sets and the population.
Although there are obvious limitations of analyses within single sources, the combination of multiple registries also can be problematic as in addition to demographic and environmental differences between populations, case ascertainment and diagnostic criteria may also differ between sources (Loane et al., 2011).
This can help address scientific and policy questions, facilitate research, compare and pool results between registries, and use the strengths contained in multiple registries to generate new insights into treatments for ESRD patients.
However, the extended database allowed much more detailed and precise estimates: For example, due to inclusion of 30,906 cases from multiple registries rather than 1,577 cases from Saarland alone, the standard error for 5-year relative survival of endometrial cancer overall decreased from 1.9%to0.4%4%.
We describe the potential for data linkage across multiple registries, which allows for access to medical histories with follow-up time spanning birth to death.
Since then, multiple registries for many types of diseases have been used to assist the clinical research process [ 9- 13].
