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Twenty-eight patients (78%) had a first recurrence of PCNSL and eight had multiple recurrent disease having failed other salvage regimens.
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Because a subset of children require multiple myringotomy and tube placements for recurrent disease, we hypothesized that children requiring repeated procedures would have effusion fluid that was more viscous and less transportable than those having their first procedure.
Intermediate-risk patients are those with pTa/pT1 G1/G2 disease who develop multiple recurrent cancers (35% of all patients).
Repeated treatment of index and recurrent disease with ciprofloxacin did not, however, prevent multiple recurrences.
During treatments for recurrent disease, she also developed multiple gastric metastases, with the same endoscopic and pathological features as the colonic lesions.
In cases with recurrent disease or second or multiple primary breast cancer, only the first primary tumour was included.
Consequently, the results of molecular epidemiologic studies of TB transmission and recurrent disease should be interpreted in light of the possibility of multiple strain infection and varying transmission.
In all, 15 (48.3%) patients had locally advanced or recurrent disease only and 16 (54.8%) presented with distant metastatic spread, with multiple site involvement in 22.5%.
It was different from the results of DESKTOP I that we found extent of recurrent disease was a survival determinant by multivariate analysis (localised lesions vs multiple lesions: HR: 1.38, P<0.0001).
The local recurrence rate was higher following ablation but there were more options for repeat intervention (either surgery or ablation) for new or recurrent disease, an important feature as most stage IV cancer patients will have multiple metastatic events.
However, she eventually developed multiple small white elevated lesions (Fig. 4a), which had not been present at the time of initial diagnosis of the recurrent disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com