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Advances in antibody engineering technologies have enabled strategies that simultaneously target multiple receptors to circumvent the limitations of conventional monospecific therapies and achieve enhanced therapeutic efficacy.
These multifunctional ligands were designed to interact with the multiple receptors to show an enhanced analgesic effect, with no opioid-induced tolerance.
A more realistic scenario is comparing the activity of multiple receptors to the same stimulus.
Medford's team also is designing plants with multiple receptors to detect more than one pollutant.
Serotonin (5-hydroxytryptamine) is a neurotransmitter that interacts with multiple receptors to mediate a wide range of effects, including involvement in anxiety and depression [ 24].
In contrast, Baker et al. found that when oscillatory receptors detect a new electric field, they reset their pattern of nerve activity, causing multiple receptors to briefly synchronize their activity.
Similar(54)
Although osteopontin is generally considered as a structural bone protein linking bone cells to the bone extracellular matrix, it has also been reported to stimulate cell activity through multiple receptors linked to several signaling pathways that relate to its function in the formation and remodeling of bone [65].
The data demonstrate the role of myocardial Gq in the initiation of myocardial hypertrophy and indicate a possible strategy for preventing pathophysiological signaling by simultaneously blocking multiple receptors coupled to Gq.
Thus, differential expression of a number of transmembrane receptor kinases with FA exposure suggests that multiple receptors belonging to different families may have unique regulatory mechanisms.
However, if multiple receptors respond to an odor, which is the more common case, is each receptor functionally redundant, so that loss of a single receptor does not affect behavioral response to the odor?
Each receptor is considered individually below; however, it is important to remember that in vivo, multiple receptors might combine to promote adhesion to endothelial cells (Refs 52, 53).
Related(20)
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