Sentence examples for multiple receptor subtypes from inspiring English sources

However, receptors that are composed of five subunits are difficult to analyse by recombinant expression of a mixture of the single subunits because multiple receptor subtypes with different subunit composition or arrangement can be formed.

5-HT exerts a wide range of effects in the gut, largely due to the presence of multiple receptor subtypes that are present on smooth muscle, enteric neurons, enterocytes, and immune cells.

The complex effects of drugs at multiple receptor subtypes in multiple tissues have made it difficult to isolate the relative contributions of GPCR regulation, ligand binding, effector coupling, drug metabolism, and cellular downregulation machinery.

Given our observations of ligand-directed G protein signalling bias, it is tempting to speculate that these multiple receptor subtypes could result from tissue-specific GLP-1 receptor-G protein couplings.

The sequence identity (93 %) of E. cautella PBAN isoforms A and C indicate that they are likely produced by alternative splicing at the 3′-end of the receptor gene as reported in other moths, generating multiple receptor subtypes [ 46].

The physiological effects of serotonin are initiated by the activation of multiple, distinct receptor subtypes.

Northern analyses showed expression of multiple somatostain receptor subtypes.

Human corticotroph adenomas also express multiple somatostatin receptor subtypes (sst receptors), with expression of sst5 predominating [ 60].

It was hypothesized that targeting multiple ErbB receptor subtypes with combined treatment of γ-tocotrienol and ErbB receptor inhibitors would provide greater anticancer effects than monotherapy targeting only a single ErbB receptor subtype.

Multiple somatostatin receptor subtypes are known to be present in medullary thyroid cancer, but actually the majority of thyroid tumours regularly express most, if not all, of the somatostatin receptor subtypes (Forssell-Aronsson et al, 2000).

The results demonstrate that carcinoid tumours possess multiple somatostatin receptor subtypes and that somatostatin analogues such as octreotide, which preferentially bind to somatostatin receptor subtype 2 and 5, can be used in the diagnosis and medical treatment of these tumours.