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The model accounts for surface exclusion effects resulting from a single quantum dot occluding multiple receptor sites.
VGSC toxins target multiple receptor sites in the sodium channel [ 35, 45].
This can be accomplished either by binding of multiple VHHs to a single LT molecule or by blocking of multiple receptor sites by a single VHH.
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We studied the densities of multiple receptor binding sites and the regionally specific balances between them in each of the 7 cytoarchitectonic areas of the IPL (Caspers et al. 2006, 2008).
Polyvalency is useful as it provides for versatile functionalization; it is also extremely important to produce multiple interactions with biological receptor sites, for example, in the design of antiviral therapeutic agents.
These observations allows to hypothesize a binding mode in which the multiple sites found in Sirt-1 might engage the putative receptor sites of AROS (5 Ser and 4 Thr residues) in a dynamic equilibrium.
We designed a Support Vector Regression (SVR) model that selects correct binding site geometries in a large ensemble of multiple receptor conformations.
Since LT contains five GM1 binding sites (Sixma et al. 1992), neutralizing VHHs must inhibit multiple receptor interactions.
Several other receptor sites for H.I.V. are known.
But drugs might be developed to block insulin receptor sites the way tamoxifen blocks receptor sites for the hormone estrogen.
The gene, CCR5, is one of the major receptor sites for the entry of H.I.V.
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