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Multiple rational combinations are possible using the motifs.
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Development of animal models more predictive of success in human trials, diversification of targets within AD, use of rational combinations to address multiple disease pathways simultaneously, and optimizing the selection of patients more likely to be responsive to antiamyloid therapies may all enhance success in AD drug development.
Our observations suggest that rational combinations of targeted therapy, which modulate multiple relevant pathways, may be useful in overcoming resistance in patients with Ewing's sarcoma.
"Smart cocktails", comprising rational combinations of therapies, need to be developed to meet this challenge.
Many other rational combinations are possible beyond those illustrated in Fig. 3.
Rational combinations determined by analysis of microarray data have been tested successfully in animal models.
These are rational combinations to further explore for the treatment of patients with advanced HCC.
Discovery of additional targets and rational combinations of targeted therapies may lead to effective novel therapies.
In order to overcome drug resistance, rational combinations of molecular targeting drugs of different signal pathways have been explored.
"This is the future," Aronne concluded, looking ahead to a better understanding of appropriate targets, treatments using rational combinations of drugs, and effective combinations of drugs with surgery.
In practice, most security forces use a more "rational" combination of race and other appropriate criteria, based on reliable statistics.
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CEO of Professional Science Editing for Scientists @ prosciediting.com