Sentence examples for multiple rare and from inspiring English sources

Our data indicates that multiple rare and common WNK1 variants contribute to BP variation and hypertension, and provide compelling evidence to initiate further genetic and functional studies to explore the role of WNK1 in BP regulation and EH.

Meanwhile, there is emerging evidence indicating that the genetic etiology of complex traits of ASDs is likely to be based on a combination of multiple rare and common susceptibility loci.

Although these figures are inevitably biased by a publishing policy favoring novel mutations, they probably also reflect the occurrence of multiple rare and few relatively common mutations in the inherited forms of these diseases.

Deep unbiased exome sequencing will also allow for burden test analyses of the combined impact on phenotype of multiple rare and low-frequency variants in a given locus or in other functional units such as a biologically relevant pathway [ 32].

In this review, an attempt is made to increase the awareness and understanding of this malady and provide an overview and not reference the multiple rare and unusual case reports, unless they contribute to the understanding of mechanisms or treatment [ 53- 63].

Recent genome-wide studies in autism, schizophrenia and Amyotrophic lateral sclerosis (ALS) suggest that multiple rare deletions and duplications should be considered as potential disease-predisposing factors [9], [38], [39].

Conversely, the Xf genome revealed a high content of externally derived DNA and several uncommon, possibly virulence-related features: a Type VI Secretion System, a second Type IV Secretion System and a distinct Type III Secretion System effector repertoire comprised of multiple rare effectors and several putative new ones.

The AT syndrome is caused by multiple rare mutations, and our data do not exclude the possibility that rare mutations of this gene may alter breast cancer risk.

Therefore, the family-based haplotype design would be expected to be a more powerful of association between a collection of multiple rare variants and disease-relevant phenotypes.

For most of other situations when disease was caused both by haplotypes with multiple rare alleles and by rare variants with similar effects, these two approaches provided similar power in testing for association.

The molecular genetic components contributing to idiopathic CHD may include accumulation of multiple rare genomic and epigenetic variants converging to dysregulate cardiac developmental genes leading to mutational loading of developmental networks [ 3].