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Although nearly the same proportion of published and unpublished trials were conducted at multiple centers 85%and87%7%, respectively more published trials than unpublished trial (43% v 23%) were conducted exclusively in the US (5.3% to 33.6%).
Ciprofloxacin remains the only quinolone to date based on multiple, head-to-head, well-controlled, published trials to have established efficacy and safety in a severely ill patient population at approved doses.
Both methods constant shallow breathing and multiple breath-hold sequences have been utilised in previously published trials [22, 23, 24, 25].
Published trials only are presented.
All included RCTs were published trials.
Sample sizes in published trials are small.
Published trials have deficiencies in their design.
This is important because most published trials have reported a non-significant trend towards a shorter duration of pregnancy after the use of progestogens in women with a multiple pregnancy [ 8, 9, 21, 22].
However, published trial outcomes were selective.
The published trial protocol provides further details.
The use of data from this large trial permits greater precision than the use of data from either a smaller study or the collection of data from multiple published studies.
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