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The PI3K-Akt pathway is known to be responsible for phosphorylation of multiple proteins such as bad and eNOS.
In mammalian cells, mitochondrial fission and fusion rely on multiple proteins, such as the dynamin superfamily, which mediate the remodeling of the outer and inner mitochondrial membranes [27].
Residing at the cytoplasmic face of early endosomes and multivesicular bodies, Hrs interacts with multiple proteins such as clathrin and EPS15 in addition to mono- and poly-ubiquitinated proteins via its ubiquitin-interacting motif (UIM) [61], [62], [63].
Matrix metalloproteinases and other proteases are also activated by ROS, further deteriorating the functions of multiple proteins such as glycolytic and antioxidant enzymes [ 7, 38].
It is also possible that this effect is due to targeting of multiple proteins such as TGFBR2 in addition to p21 by these miRNAs.
Results such as these might be further improved when multiple proteins, such as Aβ and tau, and multiple neurotoxic pathways are concurrently targeted.
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Active anticancer components are known to exhibit a consistent antitumor effect by blocking abnormal expression alterations of multiple signaling proteins, such as VEGF, p53, JAK-STAT, and CDC14A [454 55] 55].
Rab1 is a key regulator of membrane transport in the early secretory pathway of eukaryotic cells (Sherwood and Roy, 2013), and during infection it was targeted by multiple effector proteins such as DrrA/SidM and AnkX (Ingmundson et al., 2007; Machner and Isberg, 2007; Murata et al., 2006; Schoebel et al., 2009).
The fibronectin matrix is required for the assembly of multiple ECM proteins, such as type I collagen [15]; and periostin enhances the collagen cross-linking during fibrillogenesis [16], [17].
In contrast, the low passage B. burgdorferi B31 clone B31-5A18NP1 [14] exhibits a much more complex surface, where multiple abundant proteins such as Osp's might at least partially mask the expressed Vsp proteins and therefore lead to a somewhat attenuated change in phenotype.
When the Talaromyces sp. DR49 strain was grown on xylan, it was able to produce multiple accessory proteins such as xylosidase, arabinofuranosidase, cellobiohydrolase II, and β-glucosidase.
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