Furthermore, the co-expression of multiple proteins results in the formation of functional protein complex on BV, as shown by the complex between G protein-coupled receptor and heterotrimeric G protein subunits [11] as well as the four-protein complex of γ-secretase [14].
In conclusion, these data show that cocktail immunization targeting multiple (functional) salivary proteins resulted in impaired tick feeding, while immunizations with individual proteins did not have an effect.
Hence, the simultaneous measurement of the expression of multiple proteins (biomarker panels) resulted in a better discrimination between RA (or RA subgroups with different states of current activity) and controls than did the determination of the expression of one surface protein alone.
The presence of peptides common to multiple proteins may lead to erroneous results at the qualitative and quantitative levels [ 18].
One of these, MIRA-1, had promising properties in vitro but is toxic in vivo, probably because it binds to multiple protein targets extracellularly, resulting in toxicity.
In summary, this study has demonstrated how dysregulation of a single microRNA, miR-433, through its regulation of multiple protein targets results in the modulation of cell signaling pathways to induce cellular senescence and resistance to paclitaxel.
The reason for this difference might be due to the heterogeneous protein composition of FCS, which may result in multiple proteins contributing to curcuminoid solubility.
For XPD concentrations ≥6 nM, only processive activity could be detected (red line, Figure 2G), consistent with our interpretation that this activity resulted from multiple proteins.
Therefore, where in the ProteinProphet network only one protein was suitable, in the emPAI network multiple proteins gave the same results and were interchangeable.
AS in eukaryotic genomes plays an important role in augmenting biological complexity such that one gene can result in generating multiple proteins.
