The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Rahman, S. et al. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
TNF binding to the death receptor TNFR induces the conformational changes of TNFR, which recruits multiple proteins, including TNFR1-associated death domain protein (TRADD), RIPK1, TRAF2, E3 ubiquitin ligases, cIAP1/2, and LUBAC, to form TRADD and the RIPK1-dependent complex I.
MRM-MS technology can simultaneously quantify multiple proteins, including low-abundance proteins (Picotti et al. 2009), which is particularly important for precious samples such as islets.
In addition, we demonstrate that in avian tendon cells, load and growth factors stimulate phosphorylation of tyrosine residues in multiple proteins, including pp60src, a protein kinase that phosphorylates receptor protein tyrosine kinases.
The internalization of receptors is a complex process orchestrated by multiple proteins including clathrin, endocytic proteins, and adaptor proteins, which recruit their cargo into clathrin-coated pits (CCPs) [1], [2].
9 These multiple proteins include Na+ channels (Nav1.5), Cl−/HCO3− exchanger, Na+/K+ adenosine triphosphatase (ATPase), Kir6.2, and Ca2+ release channels such as those mediated by RyR2 or inositol 1,4,5-trisphosphate (IP3) receptors.
Moreover, sophisticated biosensors engineered to contain single or multiple fluorescent proteins, including FRET-based biosensors, spatiotemporally unveil molecular mechanisms underlying physiological processes.
Our data suggest that dRT-V has a potential for rapid, cost-effective, large-scale manufacturing of multiple therapeutic proteins including mAbs in response to any biological emergencies.
Multiple cellular proteins including growth factors, hormones, metalloproteinases and cell receptors are synthesized as inactive precursors [13], [14].
TRAF6 belongs to E3 ubiquitin ligase family which induces the activation of multiple signaling proteins including Akt through formation of Lysine-63-linked poly-ubiquitin chains [76].
