More recently, Gerd Kempermann of the Center for Regenerative Therapies in Dresden and colleagues examined brains from 54 individuals aged up to 100, using antibodies for multiple proteins, and found small numbers of newborn hippocampal cells in all of them.
MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways.
Recent evidence has shown that multiple proteins and biological pathways participate in the regulation of active DNA demethylation, such as TET proteins, DNA repair pathways and DNA methyltransferases.
Recently, based on the information obtained from the PDB, evidence indicates that similarities in binding sites among multiple proteins and the molecular complexity of a ligand could be reasons for the polypharmacology of drugs [18,19].
Natural products can be considered as evolutionary pre-validated ligands for multiple proteins and therefore natural products that are known to interact with one of the PSSC member proteins are selected as guiding structures for compound library synthesis.
Considering the superior sensitivity and specificity, as well as the multiplex and simple-to-implement features, this method holds great promise of becoming a routine tool for simultaneously quantitative analysis of multiple proteins and supplies valuable information for transcription factor-based early stage cancer diagnosis.
Peroxynitrite is a strongly reactive oxidant that may interact with multiple proteins and cause nitrosative modification of tyrosine residues to form nitrotyrosine.
The internal cavity of the recombinant vault is large enough to accommodate multiple proteins and we packaged the major outer membrane protein (MOMP) of Chlamydia muridarum within recombinant vaults.
At individual sites, Tup1-Ssn6 is recruited simultaneously by multiple proteins and is likely forming a multi-meric complex containing Tup1, Ssn6, multiple recruiting proteins, and chromatin remodeling factors.
However, despite the multiple proteins and pathways known to be affected by cell adhesion molecules in general and ICAM-2 in particular, complete membrane-to actin linkages that regulate CAM function in tumor cells have been difficult to identify.
Peroxynitrite interacts with and modifies multiple proteins and enzymes at tyrosine residues to form nitrotyrosine. Protein nitrotyrosylation may either up- or down-regulate activities of cellular pathways in a target-dependent manner [8] [10].
