Applications of concurrent SPRM/SPRF include the ability to monitor the the thickness and physiochemical properties of surface layers simultaneously [13], the detection and quantification of multiple analytes onto a surface [14], [15], and to study reactions between multiple proteins interacting at a surface [16].
With the knowledge of the strengths of protein-protein interactions, it is possible to gain insights into competition for binding when multiple proteins interact with the same partner and how the competition could be regulated.
In other words, we were looking for operons or "neighborhoods" of which multiple proteins interacted with multiple proteins from operons or neighborhoods elsewhere in the genome.
However, since multiple proteins interact in processes such as thrombosis, it is reasonable to hypothesize that a panel of multiple protein markers may more accurately detect a disease.
On the other hand, AMAP1 has multiple protein-interacting modules and can directly interact with different proteins, including protein kinase D2 (PRKD2) and cortactin.
Multiple proteins interact in signaling cascades, multiple cells and cell types are structured into tissue and organ systems within an individual, and multiple individual organisms interact with one another and with their environments in communities, all of which evolve and change over time.
For example, tandem repeats in many species have an evolutionary relationship with the CenH3 protein to reduce nucleosomal bending energy [ 43], multiple proteins interact with centromeric DNA to induce positive supercoiling of centromeric DNA [ 44], and CenPA (CenH3 in plants) provides the foundation for binding other kinetochore proteins [ 45].
Eukaryotic genes are transcriptionally regulated by the coordinated interaction of multiple protein factors that interact with discrete binding sites and with each other [ 20].
Most cellular processes are performed not by individual proteins acting alone, but by complexes consisting of multiple proteins that interact (bind) physically.
Furthermore, we found multiple proteins that interacted with more than two OsRFPs, including Ub family protein (Os02g06640) and jacalin-like lectin domain-containing protein (Os01g24710), six expressed proteins (Os09g00999, Os02g22130, Os10g21190, Os09g01000, Os05g02070, and Os01g15270), universal stress protein (Os05g28740), and serine/arginine repetitive matrix protein 1 (Os05g01540; Fig. 5B).
