Exact(5)
One advantage observed using multiple proteases to digest r-protein is the generation of longer peptide digestion products.
Although not specifically investigated here, the use of multiple proteases to increase protein sequence coverage should also improve quantification methods based on spectral counting.
In their strategy, they employed a series of different enrichment methods including hydrazide capture, titanium dioxide and HILIC with multiple proteases to increase glycoproteome coverage [ 45].
Most importantly, combining the use of multiple proteases to generate proteolytically unique peptides with ion mobility separation now allows for a wider mass range of proteins to be quantified.
Considering the complex role of PAR-1 in infection, related to the capacity of multiple proteases to activate PAR-1 resulting in differential cellular effects and the multiple cell types expressing PAR-1, this receptor at this moment does not represent a straightforward therapeutic target in severe pneumonia and sepsis.
Similar(55)
These results are consistent with the hypothesis that multiple proteases contribute to the biofilm-deficient phenotype of S. aureus sarA mutants [7], [8], [23].
Taken together, these results demonstrate the ability of multiple SP proteases to cleave PAP286 to various degrees, while the complete degradation of PAP286 was demonstrated by the most abundant SP protease, PSA.
This polyprotein is cleaved and translated by multiple viral proteases to form mature protein components.
Structures and associated Ki values for a lead inhibitor (CA-11) bound to uPA and to five other proteases, as well as for other leads bound to multiple proteases, help reveal the features responsible for the potency (Ki=11 nM) and selectivity of the remarkably small inhibitor, CA-11.
There is compelling evidence that apoptosis plays an important role [ 9– 11], but necrotic cell death also occurs in mouse models of photoreceptor loss and other forms of neurodegeneration [ 10], and multiple proteases have been reported to be involved in programmed cell death in 661W cone photoreceptors [ 12].
Due to its innate ability to produce and secrete multiple proteases, the extracellular environment of B. subtilis is highly proteolytic (Craddock et al. 2008).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com